Medicinal Chemistry Research Group
Research Centre for Natural Sciences, Budapest

Recent publications

  1. What is the future for fragment-based drug discovery?
    György M Keserű, Michael M Hann
    Future Medicinal Chemistry, 2017, (in press)


  2. Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes
    Diego Muñoz-Torrero, Arduino A. Mangoni, Catherine Guillou, Simona Collina, Jean Jacques Vanden Eynde, Jarkko Rautio, György M. Keserű, Christopher Hulme, Kelly Chibale, F. Javier Luque, Rafik Karaman, Michael Gütschow, Hong Liu and Rino Ragno
    Molecules, 2017, 22(5), 743.


  3. Structure-based Virtual Screening Approaches in Kinase-directed Drug Discovery
    Dávid Bajusz, György G. Ferenczy, György M. Keserű
    Current Topics in Medicinal Chemistry, 2017, 17 (20), 2235-2259.


  4. Discovery of 4-amino-3-arylsulfoquinolines, a novel non-acetylenic chemotype of metabotropic glutamate 5 (mGlu5) receptor negative allosteric modulators
    János Galambos, Attila Bielik, Gábor Wágner, György Domány, János Kóti, Zoltán Béni, Áron Szigetvári, Zsuzsanna Sánta, Zoltán Orgován, Amrita Bobok, Béla Kiss, Mónika L. Mikó-Bakk, Mónika Vastag, Katalin Sághy, Mikhail Krasavin, Krisztina Gál, István Greiner, Zsolt Szombathelyi, György M. Keserű
    European Journal of Medicinal Chemistry, 2017, 133, 240-254.


  5. Force generation by titin folding
    Zsolt Mártonfalvi, Pasquale Bianco, Katalin Naftz, György G. Ferenczy, Miklós Kellermayer
    Protein Science, 2017, (in press)


  6. Discovery and Preclinical Characterization of 3-((4-(4-Chlorophenyl)-7-fluoroquinoline-3-yl)sulfonyl)benzonitrile, a Novel Non-acetylenic Metabotropic Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulator for Psychiatric Indications
    János Galambos, Attila Bielik, Mikhail Krasavin, Zoltán Orgován, György Domány, Katalin Nógrádi, Gábor Wágner, György T. Balogh, Zoltán Béni, János Kóti, Zoltán Szakács, Amrita Bobok, Sándor Kolok, Mónika L. Mikó-Bakk, Mónika Vastag, Katalin Sághy, Judit Laszy, Attila Sándor Halász, Ottilia Balázs, Krisztina Gál, István Greiner, Zsolt Szombathelyi, and György M. Keserű
    Journal of Medicinal Chemistry, 2017, 60 (6), 2470-2484.


  7. Optical Trapping Nanometry of Hypermethylated CPG-Island DNA
    Csaba I. Pongor, Pasquale Bianco, György Ferenczy, Richárd Kellermayer, Miklós Kellermayer
    Biophysical Journal, 2017, 112 (3), 512-522.


  8. Synthesis of β-carbolines (microreview)
    Mátyás Milen, Péter Ábrányi-Balogh
    Chemistry of Heterocyclic Compounds, 2017, 52 (12), 996-998.


  9. The synthesis of α-aryl-α-aminophosphonates and α-aryl-α-aminophosphine oxides by the microwave-assisted Pudovik reaction
    Erika Bálint, Ádám Tajti, Anna Ádám, István Csontos, Konstantin Karaghiosoff, Mátyás Czugler, Péter Ábrányi-Balogh and György Keglevich
    Beilstein J. Org. Chem., 2017, 13, 76-86.


  10. Binding thermodynamics discriminates fragments from druglike compounds: a thermodynamic description of fragment-based drug discovery
    Glyn Williams, György G. Ferenczy, Johan Ulander, György M. Keserű
    Drug Discovery Today, 2017, 22 (4), 681-689.


View earlier publications