Medicinal Chemistry Research Group
Research Centre for Natural Sciences, Budapest

Daniella Takács

research fellow

Email: takacs.daniellattkmtahu
Phone: +36 1 3826 962

Scientific interests: experience in organic synthesis (Pd catalysis, cross-coupling reactions, heterocyclic chemistry), preparation of compounds from mg to two hundred gram scales for academic and industrial purpose, chromatography, NMR, LCMS, discovery and development of druglike molecules, in silico approach (basic level), QSAR

CV Publications Scopus MTMT

Selected publications

  1. Formation of a new ring system: Tetrazolo[5,1-f][1,2]azaborinin
    Daniella Takács, Péter Király, Ildikó Nagy, Petra Bombicz, Orsolya Egyed, Zsuzsanna Riedl, György Hajós
    Journal of Organometallic Chemistry, 2010, 695, 2673-2678.

  2. Selective hydroboration of dieneamines. Formation of hydroxyalkylphenothiazines as MDR modulators
    Daniella Takács, Ildikó Nagy, Petra Bombicz, Orsolya Egyed, Katalin Jemnitz, Zsuzsanna Riedl, József Molnár, Leonard Amaral, György Hajós
    Bioorganic & Medicinal Chemistry, 2012, 20, 4258-4270.

  3. A new synthetic approach to phenthiazine-2-amines
    Daniella Takács, Orsolya Egyed, László Drahos, Zsuzsanna Riedl, György Hajós
    Tetrahedron Letters, 2012, 53, 5585-5588.

  4. Synthesis and pharmacological investigation of new 2-amino-N-hydroxyalkylphenothiazines exhibiting marked MDR inhibitory effect
    Daniella Takács, Petra Bombicz, Orsolya Egyed, László Drahos, Pál Szabó, Katalin Jemnitz, Mónika Szabó, Zsuzsa Veres, Júlia Visy, József Molnár, Zsuzsanna Riedl, György Hajós
    Bioorganic & Medicinal Chemistry, 2013, 21, 3760-3779.

  5. Multidrug resistance reversing activity of newly develepoed phenothiazines on P-glycoprotein (ABCB1)-related resistance of mouse T-lymphoma cells
    Gabriella Spengler, Daniella Takács, Ádám Horváth, Zsuzsanna Riedl, György Hajós, Leonard Amaral, József Molnár
    Anticancer Research, 2014, 34, 1737-1741.

  6. Reversal of ABCB1-related multidrug resistance of colonic adenocarcinoma cells by phenothiazines
    Daniella Takács, Ákos Csonka, Ádám Horváth, Tímea Windt, Márió Gajdács, Zzuzsanna Riedl, György Hajós, Leonard Amaral, József Molnár, Gabriella Spengler
    Anticancer Research, 2015, 35, 3245-3252.